Macrophages in host defense against Histoplasma capsulatum
Identifieur interne : 002610 ( Main/Exploration ); précédent : 002609; suivant : 002611Macrophages in host defense against Histoplasma capsulatum
Auteurs : Simon L. Newman [États-Unis]Source :
- Trends in Microbiology [ 0966-842X ] ; 1999.
English descriptors
- Teeft :
- Capsulatum, Capsulatum yeasts, Cytokine, Ferric ions, Histoplasma, Host defense, Human macrophages, Immun, Immunol, Intracellular, Intraphagosomal, Macrophage, Macrophage factor, Microbiology, Microorganism, Monocyte, Murine, Murine macrophages, Phagocytosis, Phagosome, Phagosomes, Receptor, Respiratory burst, Strasser, Transferrin, Yeast.
Abstract
Abstract: Macrophages function in both innate and cell-mediated immunity in host defense against pathogenic fungi. They initially serve as a protected environment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from the lung to other organs. Upon induction of cell-mediated immunity, cytokines activate macrophages to destroy the yeasts and thus remove them from the host.
Url:
DOI: 10.1016/S0966-842X(98)01431-0
Affiliations:
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Le document en format XML
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